We don’t need any more reasons for Glucagon-Like Peptide-1 Receptor Agonists to be called the “Drugs of the Century,” but medscape.com just came up with a new one. It happens to be the “potential anti-aging benefits…..for adults over age 65.” Yes, semaglutide and tirzepatide must have been what Ponce de Leon found in the fountain of youth.
“Natural” aging has the following effects on the human body:
Decline in kidney function—chronic kidney disease
Dehydration
Coronary Artery Disease
Congestive Heart Failure
Stroke
Dementia
Decrease in Muscle Mass—atrophy
Osteoporosis
Low Blood Pressure/Fainting
GLP-1’s and their anti-aging properties, affect each of these problems in a beneficial way.
Glucagon-Like Peptide-1 Receptor Agonists do the following:
Improve kidney function
Improve blood flow
Reduce Heart Failure Risk
Lower stroke risk
Fend off the onset of dementia.
Daily protein consumption and exercise prevent muscle loss.
CA++ and Vitamin D are enhanced
Weight loss can lower BP and cause fainting. Stop BP meds.
Improved hydration
Adults over age 65 will lose weight but also delay aging changes by using GLP-1’s. Close monitoring and taking the supplements that prevent age-related changes are essential.
Reference: Warburg M. GLP-1’s in Older Adults: Benefits and Risks to Watch. Medscape 2025 September 18.
